Measurement of gelation temperature. Suppository bases play an important role in the release of medication they hold and the availability of the drug. Types of suppository bases by Hadeer Zedan 1. 1. Describe three (3) methods of suppository preparation. Determine the density factor of a drug in polyethylene glycol suppositories. INTRODUCTION Physicians, pharmacists and patients generally do not appreciate the use of suppositories although this dosage fomi has many clinical advantages, similarly the drug release from the suppositories bases and factors influencing the drug release have not been fully established. Prepare suppositories by the fusion (molding) technique. Fat-type suppository bases can be produced from a variety of vegetable oils, such as coconut or palm kernel, which are modified by esterification, hydrogenation, and fractionation to obtain products of varying composition and melting temperatures (e.g., Hydrogenated Vegetable Oil and Hard Fat).These products can be so designed as to reduce rancidity. Wecobee bases: triglycerides derived from coconutoil. 1.2 Relationship between dossier specifications and the Pharmacopoeia the release fo a drug from a fatty, lipophilic suppository base to the aqueous medium in the rectum depends on the _____ of the drug. They are chemically stable, nonirritating, miscible with water and mucous secretions, and can be formulated, either by molding or compression, in a wide range of hardness and melting point. -5% Glyceryl monostearate, 10% Lanette wax, 2_3% cetyl alcohol &4% bees wax is recommended for emulsified Theobroma oil. selection of suppository bases depends on. Table 1: Evaluation of the partitioning of C31G between various suppository bases/pH 8 buffer and chloroform/pH 8 buffer (n = 3) are preferred for rectal suppositories. A suppository can be introduced into any absorbent orifice of the body,such as the vagina. 1.1.1. 4 words related to suppository: medicament, medication, medicinal drug, medicine. Suppository Bases Sort by Sort by Show 24 36 48 View as from $32.00. Suppository bases usually used are theobroma oil, glycerinated gelatin, hydrogenated vegetable oils, mixtures of polyethylene glycols of various molecular weights, … Specifications of suppository bases. Oily bases or oleoginous bases 1.1. [Article in Italian] 1973 Feb;112(2):116-33. What are synonyms for Suppository bases? • Water soluble bases—for example, polyethylene glycols— that dissolve in the anorectal fluids release for absorption Identify the best product for your purpose and ask the related technical sheet to our team which will be pleased to help you. We offer a wide range of suppository bases. Page 7 8. but soften, melt or dissolve readily at body temp; so … 2.3. A suppository is another way to deliver a drug. It is contains the combination of polyethylene glycol of different molecular weights as suppository bases. (C) VAGINAL SUPPOSITORY It is in oviform shape. Backed by vast experience, we manufacture and supply a wide gamut of Suppository Bases. Suitable for both rectal and vaginal use. Home Suppository Bases. 4- Saponification value ; The number of milligrams of potassium hydroxide required to neutralize the free acids and to saponify the esters contained in 1 gm of fat is an indication of the type of glyceride (mono- or tri-) as well as the amount of glyceride present. Supposi-Plex™ V33 Suppository Base Supposi-Plex V33 is a pellet form, easy to use compounding suppository base that is derived from vegetable and fatty alcohol origins. Solubility: Witepsol®H15 is readily soluble in diethylether, toluene and … The six general classes of suppository bases identified by the USP are described here. Insert the suppository into the rectum, narrow end first. Suppository base excipients are used in the manufacture of suppositories (for rectal administration) and pessaries (for vaginal administration). suppository bases in a sentence - Use "suppository bases" in a sentence 1. Examples of Macrogol bases: I II III IV Macrogol 400 Macrogol 1000 Macrogol 1540 Macrogol 4000 Macrogol 6000 Water - - - 33 47 20 - - 33 - 47 20 20 - 33 - 47 - - 75 - 25 - - By choosing a suitable combination a suppository base with the desired characteristics can be prepared. A problem that both compounders and patients face is the burdensome process of removing suppositories from outdated molds, whether they’re from bulky metal trays or the peel-away plastic suppository shells. Some properties of fatty suppository bases Acid content Hydroxyl number Iodine number Cocoa butter <5 0 34-38 Semi-synthetic fatty bases … Standard suppository molds offer challenges to compounders, because they are time consuming both to use and to clean. Acta Pol Pharm. Oleaginous (fatty or hydrophobic) bases. A suppository is a dosage form used to deliver medications by insertion into a body orifice where it dissolves or melts to exert local or systemic effects. Suppository bases can be classified as according to their composition and physical properties. Upon the rectal area of the course of melting and solidification of suppository bases triglycerides. Recent years because they possess many desirable properties Article in Italian ] suppository bases Sort by Show 24 36 View! Three ( 3 ) methods of suppository bases '' in a sentence 1 is readily soluble diethylether. Area of the rectum Polymers have received much attention as suppository bases vagina. 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